| Chemical Biology of Secondary Metabolism

Mass Spectrometry

Mass spectrometry guided discovery of novel secondary metabolites, facilitates the discovery of novel compounds, potentially new drugs. Imaging mass spectrometry can visualize the metabolites of microbiomes, in the environment or in the clinic.

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Welcoming Courtney, Haley and Amanda in the lab!

Drug discovery

Bioassay guided discovery of novel secondary metabolites (natural products) from new microbial sources, combined with computational mining of biosynthetic clusters, evoltion-based screening, and mass spectrometry, will lead to new drugs.

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Recent publications

03.30.2017

Mechanistic crosslinking in the classroom

Journal of Chemical Education article by Kara Finzel! Published in JCE.

03.30.2017

New probes for crosslinking

Lou Charkoudian's lab shows a nice new way to crosslink carrier proteins and partner proteins. Published in Biochemistry.

Metabolic engineering

Changing the flux of metabolites in an organism allows us to produce high-value molecules in several hosts. The introduction of new enzymes or the deletion of native enzymes, facilitates the production of fuel, plastics, drugs and others, in bacteria.

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